Parents

• Mason Loch "Parson" Weems (1759–1825)
• Frances Ewell (Fanny) (1775–1843)

Spouses

• Ascenath Otis Slade (1809–1899)

Siblings

• Frances Ewell Weems (1796–1813)
• Susan Ann Weems (1798–1821)
• Jesse Ewell Weems Rev. (1799–?)
• Charlotte Ewell Weems (1801–1843)
• Nancy Ewell (Ann) Weems (1802–1833)
• Harriet Ewell Weems (1804–?)
• Marion Weems d.inf (1808–1809)
• Francis Marion Weems Dr. (1809–1865)
• Milton Weems d.inf (1812–1813)

Children

• Mason Locke Dr. Weems III (1831–1917)
• Charles Henry Weems d.inf (1842–1843)
• Zuleika Asenath Weems (1839–1891)
• John Milton Weems Rev. (1847–1862)
• Richard Slade Weems (1849–1867)

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